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DNA Damage & Repair

DNA contains the essential genetic information in living cells. When cells grow and divide they need to ensure correct replication of DNA and to repair any mistakes or mutations. Accumulation of these mutations if not properly repaired can lead to uncontrolled cell growth that is the hallmark of cancer. Understanding DNA damage and repair mechanisms helps researchers to identify the aberrant processes that drive cancer development and growth. 

 

DNA Damage and Disease Group

We study the signalling mechanisms cells use to respond to DNA damage and why defects in these...

 
Nucleic Acids Research Group

We design and synthesise chemically modified DNA for diagnostic and therapeutic applications....

 
Cancer therapeutics, DNA damage and repair laboratory

A major focus of our work is exploring how ATRX prevents normal cells from elongating their...

 
Cell Cycle and Ubiquitin Mediated Proteolysis Group

Our group objective is to identify novel pathways governing cell proliferation, which are...

 
Biochemistry and Regulation of DNA Repair Group

The long-term goal of the Dianov Laboratory is to study the proteins and mechanisms involved in...

 
Chromosome Integrity Group

The aim or our research is to understand how genome stability is maintained in response to DNA...

 
DNA Repair in Cancer Treatment Group

We are investigating DNA damage signalling and repair factors in bladder cancer to develop new...

 
Cancer Cell Cycle Group

Research in Nick La Thangue’s group focusses on the mechanisms that give rise to the abnormal...

 
DNA Damage and Repair Group

We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and...

 
DNA Repair and Replication Group

We are working towards elucidating how cells resolve replicative stress arising from endogenous...

 
DNA Damage Group

Our research involves looking in to the process of radiation induced cluster DNA damage.

 
DNA Damage Response Group

We are interested in the role of the ubiquitin-proteasome system in DNA repair, ageing, cancer...

 
Genome Stability and Tumourigenesis Group

Our research is focused on gaining a greater understanding of how homologous recombination (HR...

 
About Us
We aim to enhance clinical and basic cancer research in Oxford with the ultimate goal of increasing cancer cure rates.
Research
In Oxford, we have a great wealth of broad-ranging expertise and a powerful network of cancer researchers.
Study With Us
Our graduate training programmes for both scientists and clinicians are internationally recognised.