Our group focuses on using imaging techniques in small-scale trials with the particular ambitions of improving the mechanisms of data analysis and correlating the imaging data provided with histology and treatment outcomes.
We have also developed novel data analysis techniques for use in hyperpolarized xenon MRI. Trials in normal healthy volunteers, patients with COPD and lung cancer are currently underway, and have enabled us to develop methods of lobar analysis of ventilation and emphysema correlated with CT and pulmonary function. The aim is to develop an imaging tool that would, for instance, predict the change in lung function following lobar resection or following radiotherapy.
3-D hyperpolarized xenon ventilation MRI image
Fergus Gleeson is a Consultant Radiologist and Professor of Radiology in Oxford. He trained in Cambridge, Papworth and London, and was a Fellow in Radiology at UCLA in Los Angeles. He was appointed to Oxford in 1992, and is head of academic radiology, the director of the Oxford Imaging Trials Unit, and a Divisional Director for the Oxford University Hospitals NHS Trust. His specialist interests are in PET and hyperpolarized xenon MRI.
The impact of heterogeneity and uncertainty on prediction of response to therapy using dynamic MRI data. Bhushan M, Schnabel JA, Chappell M, Gleeson F, Anderson M, Franklin J, Brady SM, Jenkinson M. Med Image Comput Comput Assist Interv. 2013;16(Pt 1):316-23
Differences in the biologic activity of 2 novel MEK inhibitors revealed by 18F-FDG PET: analysis of imaging data from 2 phase I trials.Kraeber-Bodéré F, Carlier T, Naegelen VM, Shochat E, Lumbroso J, Trampal C, Nagarajah J, Chua S, Hugonnet F, Stokkel M, Gleeson F, Tessier J. J Nucl Med. 2012 Dec;53(12):1836-46.
Metabolic response at repeat PET/CT predicts pathological response to neoadjuvant chemotherapy in oesophageal cancer. Gillies RS, Middleton MR, Blesing C, Patel K, Warner N, Marshall RE, Maynard ND, Bradley KM, Gleeson FV. Eur Radiol. 2012 Sep;22(9):2035-43.
Ambika Talwar, Clinical Research Training Fellow