Radiation Biophysics Core
The Radiation Biophysics Core develops and supports a unique range of radiation resources and techniques along with providing associated expertise. These facilities range from those used for basic cell irradiations (including techniques capable of manipulating radiation fields on the sub-cellular micron scale), through to supporting and developing a SARRP image guided pre-clinical x-ray irradiator and also includes developing techniques for dosimetry on clinical machines.
One of the main research interests includes investigating how and why ionising radiation initiates a diverse range of biological responses. We are also interested in how this correlates to differences in the temporal and spatial pattern of energy deposition events on the scale of DNA, cells and tissues associated with different radiation qualities of ionizing radiation. Mechanisms are thus formulated which are interpreted in the context of risk associated with exposure or which can potentially be exploited in radiotherapy.
Mark Hill has been Head of the Radiation Biophysics Core at the CRUK/MRC Oxford Institute for Radiation Oncology within the Department of Oncology since 2008, following the move of his research group from the MRC Radiation and Genome Stability Unit.
Mark has over 30 years of experience in the field of radiation biology and physics with 70 plus related peer-reviewed publications, building on an MSc in Radiation Physics at St Bart’s Medical College and related PhD at Queen Mary and Westfield College, University of London, prior to moving to the MRC Unit in 1994. The main focus of the work over this period relates to understanding the mechanisms behind initial DNA damage and subsequent biological response in the context of radiation track structure and ultimately the associated human health implications. Following the move to the University of Oxford his interests have expanded to include, not only in vivo and preclinical experiments, but also clinically related research.
Mark is Course Director of the MSc in Radiation Biology in the Department of Oncology. In addition to teaching on this course, he is a specialist radiobiology examiner on the First FRCR examination board for the Royal College of Radiologists and lectures on the Annual Radiological Protection Summer School held at the University of Cambridge. He has also been involved with a number of national and international committees including being a member of the International Agency for Research of Cancer (IARC) working group preparing the monograph on ionising radiation and cancer, a member of the International Commission on Radiation Units and Measurements (ICRU) working group on the dosimetry of low-dose exposures of ionsing radiation and a member of the Tritium Subgroup of the UK Advisory Group on Ionizing Radiation (AGIR).
Mark is also a member of the ESTRO ACROP task group on Technology for Precision Small Animal Radiotherapy Research and has recently been appointed as a member of the NCRI Clinical and Translational Radiotherapy Working Group (CTRad) for Workstream 1 (Science Base).
Selected peer reviewed publications:
M.A. Hill. Cardiac MR imaging genotoxicity? Eur Heart J. 39, 313-325 (2018) [PMID: 29281062]
F. Verhaegen, L. Dubois, S. Gianolini, M.A. Hill, C.P. Karger, K. Lauber, K. M. Prise, D. Sarrut, D. Thorwarth, C. Vanhove, B. Vojnovic, R. Weersink, J. J. Wilkens, D. Georg, Technology for Precision Small Animal Radiotherapy Research: optimal use and challenges, Radiotherapy and Oncology. 126, 471-478 (2018)[PMID: 29269093]
M. Durante, E. Brauer-Krish, M.A. Hill. Faster and safer? FLASH ultra-high dose rate in radiotherapy. Br J Radiol. 91, 20170628 (2018) [PMID: 29172684]
M.A. Hill. Track to the future: historical perspective on the importance of radiation track structure and DNA as a radiobiological target. Int. J. Radiat. Biol. In Press, available online 8 December 2017 [PMID: 29219655]
R. Carter, C. Nickson, J.M. Thompson, A. Kacperek, M.A. Hill, J. Parsons, Complex DNA damage induced by high-LET α-particles and protons triggers a specific cellular DNA damage response. Int J Radiat Oncol Biol Phys. 100, 776-784 (2018) [PMID: 29413288]
P. Abnave, E. Aboukhatwa, N. Kosake, J.M. Thompson, M.A. Hill and A.A. Aboobaker, Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians. Development, 144, 3440-3453 (2017) [PMID: 28893948]
A. Corroyer-Dulmont, N. Falzone, V. Kersemans, J. Thompson, D. P. Allen, S. Able, C. Kartsonaki, J. Malcolm, P. Kinchesh, M.A. Hill, B. Vojnovic, S.C. Smart, M.N. Gaze, and K.A. Vallis. Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma. Radiother. Oncol. 124, 488–495 (2017) [PMID: 28595752]
M.A. Hill, J.M. Thompson, A. Kavanagh, I.D.C. Tullis, R.G. Newman, J. Prentice, J. Beech, S. Gilchrist, S. Smart, E. Fokas, B. Vojnovic. The Development of Technology for Effective Respiratory-Gated Irradiation Using an Image-Guided Small Animal Irradiator. Radiat. Res. 188, 247-263 (2017) [PMID: 28715250]
V. Kersemans, J.S. Beech, S. Gilchrist, P. Kinchesh, P.D. Allen, J. Thompson, A.L. Gomes, Z. D'Costa, L. Bird, I.D.C. Tullis, R.G. Newman, A. Corroyer-Dulmont, N. Falzone, A. Azad, K.A. Vallis, O.J.Sansom, R.J. Muschel, B. Vojnovic, M.A. Hill, E. Fokas, S.C. Smart. An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse. PLoS One. 12(4):e0176693 (2017). [PMID: 28453537]
R. Morrison, M. Rybak-Smith, J. Thompson, B. Thiebaut, M.A. Hill, H.E. Townley, Efficacy of radiosensitizing doped titania nanoparticles under hypoxia, and preparation of an embolic microparticle. Int. J. Nanomedicine. 12, 3851-3863 (2017) [PMID: 28572729]
A. Corroyer-Dulmont, N. Falzone, V. Kersemans, J. Thompson, M. Hill, P.D. Allen, J. Beech, S. Gilchrist, P. Kinchesh, B. Vojnovic, I. Tullis, M.N. Gaze, S. Smart, K.A. Vallis. MRI-guided radiotherapy of the SK-N-SH neuroblastoma xenograft model using a small animal radiation research platform. Br. J. Radiol. 90, 20160427 (2017) [PMID: 27524406]
M.A. Hill, P. O’Neill and W.G. McKenna, Comments on potential health effects of MRI-induced DNA lesions: quality is more important to consider than quantity. Eur Heart J Cardiovasc Imaging. 17, 1230-1238 (2016) [PMID: 27550664]
M.A. Hill and B. Vojnovic, Implications of respiratory motion for small animal image-guided radiotherapy. Br. J. Radiol. 90, 20160482. (2017) [PMID: 27384471]
A.B. Abdelrazzak, S. J. Pottgießer, M.A. Hill, P. O`Neill and G. Bauer, Enhancement of peroxidase release from non-malignant and malignant cells through low-dose irradiation with different radiation quality. Radiat. Res. 185, 199-213 (2016) [PMID: 26849404]
S.J. Seo, S.M. Han, J.H. Cho, K. Hyodo, A. Zaboronok, H. You, K. Peach, M.A. Hill, and J.K. Kim, Enhanced production of reactive oxygen species by gadolinium oxide nanoparticles under core–inner-shell excitation by proton or monochromatic X-ray irradiation: implication of the contribution from the interatomic de-excitation-mediated nanoradiator effect to dose enhancement. Radiat. Environ. Biophys. 54, 423 (2015) [PMID: 26242374]
R. Morrison, J. Thompson, L. Bird, M.A. Hill and H. Townley, Synthesis and characterization of polystyrene embolization particles doped with tantalum oxide nanoparticles for X-ray contrast. J. Mater. Sci: Mater. Med. 26, 5549 (2015) [PMID: 26223792]
B.L. Tracy, D.L. Stevens, D.T. Goodhead and M.A. Hill, Variation in RBE for survival of V79-4 cells as a function of alpha-particle (helium ion) energy. Radiat. Res. 182, 33-45 (2015) [PMID: 26121227]
D. Warren, M. Partridge, M.A. Hill and K. Peach, Improved calibration of mass stopping power in low density tissue for a proton pencil beam algorithm. Phys. Med. Biol. 60, 4243-4261 (2015) [PMID: 25973866]
M.A. Kadhim and M.A. Hill, Non-targeted effects of radiation exposure: recent advances and implications. Radiat. Prot. Dosim 166, 118-124 (2015) [PMID: 25897137]
L.G. Mariotti, A.B. Abdelrazzak, A. Ottolenghi, P. O'Neill and M.A. Hill, Stimulation of intercellular induction of apoptosis in transformed cells at very low doses of ionising radiation: spatial and temporal features. Radiat. Prot. Dosim. 166, 161-164 (2015) [PMID: 25883313]
M.A. Hill, Fishing for radiation quality: Chromosome aberrations and the role of the radiation track structure. Radiat. Prot. Dosim. 166, 295-301 (2015) [PMID: 25883310]
T.S.A. Underwood, J. Thompson, L. Bird, A.J. Scott, P. Patmore, H.C. Winter, M.A. Hill and J.D. Fenwick, Validation of a prototype DiodeAir for small field dosimetry. Phys Med Biol. 60, 2939-2953 (2015) [PMID: 25789823]
G.B. Curwen, N.V. Sotnik, K. K. Cadwell, T.V. Azizova, M.A. Hill and · E.J. Tawn, Chromosome aberrations in workers with exposure to α-particle radiation from internal deposits of plutonium – expectations from in vitro studies and comparisons with workers with predominantly external γ-radiation exposure, Radiat. Environ. Biophys. 54, 195-206 (2015) [PMID: 25649482]
James Thompson, Postdoctoral Researcher
Amy Elliot, Research Assistant