Title

IPI-GLIO

Chief Investigator: 
Dr Paul Mulholland

 

 

 

Full Title: A Phase II, Open Label, Randomised Study of Ipilimumab with Temozolomide versus Temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma

Sponsor: University of Oxford

Trial Design:

This is an unblinded, open labelled stratified randomised Phase II multicentre clinical trial (CTIMP). Patients with newly diagnosed de-novo glioblastoma following surgery or biopsy and radical radiotherapy with concomitant temozolomide will be recruited from 5-7 sites in the UK.

Status

Set-Up

Recruitment

Target:120 Patients

Primary Objective:

To evaluate whether the addition of ipilimumab to the current standard of care following surgery and chemoradiotherapy will improve survival in patients with newly diagnosed glioblastoma

Secondary Objective:

To evaluate the safety and tolerability of ipilimumab plus temozolomide

 

Target Opening to Recruitment: 07 December2018

Funding: The study is funded by Bristol Myers-Squibb and The National Brain Appeal.

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