Title

OCTOVA

Chief Investigator: 
Dr Shibani Nicum

Paclitaxel, olaparib and cediranib in BRCA mutated platinum-resistant ovarian cancer.

This multi-centre, randomised, open-label phase II trial will compare the activity and toxicity of chemotherapy (weekly Paclitaxel) to a novel agent Olaparib, and also Olaparib to the combination of Olaparib and Cediranib in women with advanced ovarian cancer and a gene mutation (BRCA gene). Olaparib is expected to be as active but less toxic than chemotherapy. This will be the first time that the combination of Olaparib and Cediranib has been tested in women with multiply relapsed platinum resistant ovarian cancer and a BRCA mutation.

OCTOVA is being funded by an educational grant from AstraZeneca (AZ) as part of the AZ-ECMC alliance. The trial is currently in setup and recruitment is expected to start in the summer of 2016. We plan to recruit 132 patients in 14 UK-wide sites.

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