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Aryl boronate fluorescent probes allow the non-invasive study of dynamic cellular processes involving the reactive species, hydrogen peroxide (H2O2) and peroxynitrite (ONOO-). However, the ability of these probes to differentiate between these two species remains unclear. Here, we report a boronate-functionalised hemicyanine dye (HD-BPin) as a potential strategy to distinguish between H2O2 at 704 nm (red channel) and ONOO- at 460 nm (blue channel) in solution and in cells. This work also highlights the choice of fluorophore before boronate functionalization can dictate the observed selectivity between these two species.

Original publication

DOI

10.1039/d2cc03406a

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

22/09/2022

Volume

58

Pages

10699 - 10702

Keywords

Fluorescent Dyes, Hydrogen Peroxide, Peroxynitrous Acid