Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pK(a) vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pK(a) analogues.

Original publication

DOI

10.1039/b803262a

Type

Journal article

Journal

Mol Biosyst

Publication Date

07/2008

Volume

4

Pages

741 - 745

Keywords

DNA, Disulfides, Gene Transfer Techniques, Genetic Vectors, Kinetics, Microscopy, Atomic Force, Peptides