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To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

Original publication

DOI

10.1038/ng.993

Type

Journal article

Journal

Nat Genet

Publication Date

27/11/2011

Volume

44

Pages

58 - 61

Keywords

Case-Control Studies, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 7, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Multiple Myeloma, Polymorphism, Single Nucleotide, Protein Serine-Threonine Kinases, Risk Factors