Attachment of vitamin E derivatives to oligonucleotides during solid-phase synthesis
Will DW., Brown T.
Compounds have been synthesized which allow the attachment of Vitamin E to the 5′-, and 3′-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5′-end, all during solid-phase synthesis. The effects on cellular uptake, distribution, and antiviral activity of the attachment of the extremely lipophilic Vitamin E moiety to phosphorothioate 'antisense' oligonucleotides are now being investigated. © 1992.