Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
Vickaryous N., Polanco-Echeverry G., Morrow S., Suraweera N., Thomas H., Tomlinson I., Silver A.
We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+).