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Immunoprecipitation of [35S]methionine-labeled cell extracts and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that cells from two human choriocarcinomas JaR and BeWo contained beta 2-microglobulin. The JaR cells, and one subline of BeWo, did not express surface HLA-A, -B, and -C (HLA-ABC) antigens, nor did JaR contain the antigens when cell-free extracts were measured in a sensitive radioimmunoassay. It may be concluded that the lack of expression of HLA-ABC antigens in choriocarcinoma (and in the trophoblast) is not a result of lack of beta 2-microglobulin, as is the case for the Burkitt's lymphoma cell line, Daudi.

Type

Journal article

Journal

J Exp Med

Publication Date

01/08/1980

Volume

152

Pages

11s - 17s

Keywords

Animals, Beta-Globulins, Cell Line, Choriocarcinoma, Female, HLA Antigens, Humans, Pregnancy, Uterine Neoplasms, beta 2-Microglobulin