Energy regulation: HIF MXIes it up with the C-MYC powerhouse.
Sutphin PD., Giaccia AJ., Chan DA.
The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2007 issue of Cancer Cell, Zhang and colleagues determine that the hypoxia-inducible factor family of transcriptional factors regulate mitochondrial biogenesis through inhibition of C-MYC.