Nanoparticle-based Antigen Specific Immunotherapy
McAteer M., Dayan C., Birchall J.
The present invention provides a nano particle comprising: a core comprising metal atoms; a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprises: at least one carbohydrate ligand; at least one glutathione ligand; and at least one autoantigen peptide ligand. Also provided are compositions and vaccines comprising the nanoparticles, methods for producing the nanoparticles and medical uses of the nanoparticles, including for antigen specific immunotherapy of an autoimmune disease, such as diabetes mellitus type 1, in a mammalian subject.