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The Oncology Clinical Trials Office (OCTO) provides clinical trial management support to investigators across the CRUK Oxford Centre to manage trials from concept to completion.

OCTO was established in 2002 to run trials concerned with the practical application of high quality research into innovative and effective cancer therapies and prevention strategies. We aim to become the leading centre for translational early phase oncology trials in the UK.

We work with investigators to deliver trials in medical oncology, radiotherapy and imaging from first-in-human drug trials to large phase 3 clinical studies across a range of tumour types.  We have particular expertise in delivering early phase multi-centre trials for biologically distinct populations. By working with over 250 study sites (hospitals) and collaborating academic groups in the UK, Europe, USA and Australia we have recruited over 10,000 patients into trials.

We have established excellent relationships with academic groups, research communities, industry and patients to support the work of all our partner organisations:

We also work closely with colleagues in the state-of-the-art NHS Oxford Cancer and Haematology Centre to ensure that opportunities for collaborative research are maximised and that research is rapidly and efficiently translated into cutting-edge clinical treatment for cancer patients.

OCTO is the oncology division of the UKCRC registered Oxford Clinical Trials Research Unit (OCTRU) and a member of the NCRI Cancer CTUs Working Group.

Our trial portfolio

The portfolio includes a range of projects from first in human drug trials through to large Phase III clinical studies. Studies assess interventions including radiotherapy, drug combinations and novel imaging techniques.

Our current portfolio is divided into 3 categories:
  • Early Phase
  • Radiotherapy and Imaging
  • Data-Rich Trials

Tumour types include: colorectal, oesophageal, melanoma, lung, breast, cervical, haematology, and bone sarcoma, in both adjuvant and advanced disease.

Scientific focus includes: angiogenesis, hypoxia, biomarkers and signalling pathways to improve the specificity of cancer treatment.

Details of our current portfolio can be found here.


OpenClinica is the world's leading open source clinical trial software for electronic data capture and clinical data management. Information on how to use OpenClinica can be found in the OpenClinica Training section below. There is a user guide and instructional videos to show you how to use OpenClinica.  After reviewing these if you have any other queries please contact a member of the trial team at OCTO.

OpenClinica home page: OpenClinica Live

OpenClinica training page: OpenClinica Test


OpenClinica Site User Guide


OpenClinica Data Entry: 

OpenClinica Discrepancies:

Please contact the trial team at OCTO if you have any problems viewing the videos or opening the user guide. Tel: +44 (0)1865 617000 or use the contact details from the relevant trial page.