Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A single arm exploratory study examining the feasibility of imaging glioblastoma pH using CEST MRI

IMAGO trial logo

 

 

 

 

Full Title

A single arm exploratory study examining the feasibility of imaging glioblastoma pH using CEST MRI

Chief Investigator:  Simon Lord

ISRCTN Identifier: ISRCTN86522205

Sponsor: University of Oxford

Study Design

Single arm exploratory

Study Population

Previously untreated glioblastoma patients scheduled for resection or debulking.

Study Status

Closed to Recruitment

Study Schema

 IMAGOStudySchema.png

Inclusion Criteria

  1. Participant is willing, capable of cooperating with the protocol and able to give informed consent for participation in the study.
  2. Male or Female, aged 18 years or above.
  3. Diagnosed with glioblastoma and scheduled for neurosurgical resection or debulking.

Exclusion Criteria

  1. Intolerant of MRI brain (for example: claustrophobia).
  2. MRI brain contraindicated (for example: implanted electric and electronic devices, heart pacemakers, insulin pumps, implanted hearing aids, neuostimulators, intracranial metal clips, metallic bodies in the eye).
  3. Neoadjuvant chemotherapy/radiotherapy treatment for glioblastoma which would interfere with the interpretation of trial results.
  4. Pregnancy.
  5. Other psychological, social or medical condition that the investigator considers would make the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of trial results.

Primary objective

To evaluate CEST contrast image obtained from CEST MRI in glioblastoma

Secondary Objectives

  • Explore if measurement of tumour protein levels relates to CEST MRI imaging signal
  • Explore if measurement of tumour pH relates to CEST MRI imaging signal
  • Explore if hypoxia relates to CEST MRI imaging signal
  • Explore if ASL MRI perfusion imaging signal relates to CEST MRI imaging signal

IMAGO Trial Office (OCTO)

General Enquiries:

Tel: +44 (0)1865 617 083

Fax: +44 (0)1865 617 010

On this page