VISTA: A first in human, open-label, randomised, controlled phase 1/2a study to assess the safety, tolerability, immunogenicity and early anti-tumour response with ITOP1 a prime/boost viral vector vaccine targeting tumour specific antigens in subjects with surgically resectable oesophageal cancer
The VISTA study will explore the safety, tolerability, immunogenicity and early clinical activity of ITOP1 administration in patients with resectable oesophageal adenocarcinoma (OAC) in reducing the risk of disease relapse.
ITOP1 is a novel adenoviral-based, anti-cancer vaccine that utilises a homologous prime-boost viral vector regimen. To elicit a broad anti-tumour response and to optimise for potential benefit across the target patient population, ITOP1 will be a multiepitope vaccine where patients receive up to 6 recombinant adenovirus type-5 (Ad5) vectors, each transduced with one of 6 minigene sequences to deliver novel oesophageal cancer-specific antigens.
Viral delivery of these selected epitopes, via a prime-boost vaccination regimen, is expected to result in T cell recognition of the ensuing peptide-human leucocyte antigen (HLA) complexes, which will prime minigene antigen-specific T cells, resulting in their activation and proliferation. Subsequent exposure of the oesophageal cancer-specific antigens to the primed T cells boosts this response, promoting persistence, further activation, and expansion of the antigen-specific T cell pool, enhancing the clinically desirable anti-tumour T cell memory response.
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- Current Trials
- Trials in Set Up
- CHARIOT: M6620 plus standard treatment in oesophageal and other cancer
- LUD 2015-005: ANTI-PD-L1 in combination with chemo(radio)therapy for oesophageal cancer
- SCALOP-2: Systemic therapy and Chemoradiation in Advanced Localised Pancreatic cancer–2
- CYTOFLOC: Cytosponge™ for post‐chemoradiation surveillance of oesophageal cancer
- FRONTIER: Fluciclovine (18F) imaging of breast cancer
- NuTide:301: Safety, pharmacokinetics and clinical activity of NUC-3373, a nucleotide analogue, in participants with advanced solid tumours.
- IMAGO: A single arm exploratory study examining the feasibility of imaging glioblastoma pH using CEST MRI
- TARDOX: Targeted chemotherapy using focused ultrasound for liver tumours
- CAMELLIA: Anti-CD47 antibody terapy in relapsed/refractory Haematological Malignancies
- ATOM: Atovaquone as Tumour HypOxia Modifier
- 6MP: A Phase II Clinical Trial in Patients with BRCA Defective Tumours
- AspECT: A Phase III, Randomised, study of Aspirin and Esomeprazole Chemoprevention in Barrett’s Metaplasia
- BKM120: Palliative thoracic radiotherapy plus BKM120
- CHOP-OR: Study of CHOP with Ofatumumab in Patients with Richter's Syndrome
- NEOPANC-01 - Pre-operative, Window-of-opportunity Study to Assess Gene Expression in Patients With Resectable, Locally Advanced, or Metastatic Pancreatic Cancer
- COG : Gefitinib for oesophageal cancer progressing after chemotherapy
- DATACAP: Dose Adaptation of Capecitabine Using Mobile Phone Toxicity Monitoring
- DEBIOC: Dual Erb B Inhibition in Oesophago-gastric Cancer
- DOC-MEK: A double-blind randomized phase 2 trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma
- EnROL: Conventional versus laproscopic surgery for colorectal cancer within an enhanced programme
- FOXFIRE: An open-label randomised phase III trial of 5-Fluorouracil, OXaliplatin and Folinic acid +/- Interventional Radio-Embolisation as first line treatment for patients with unresectable liver-only or liver-predominant metastatic colorectal cancer
- LINES: Eurosarc Trial of Linsitinib in advanced Ewing Sarcoma
- MErCuRIC1: MEK and MET Inhibition in Colorectal Cance
- MPP: Application of mobile phone technology for managing chemotherapy-associated side-effects
- OXO-PCR-01: Oxford Ovarian Cancer Predict Chemotherapy Response 01
- PACMEL: A randomised phase 2 study of paclitaxel with or without GSK1120212 or pazopanib in advanced wt BRAF melanoma
- PemBla: A parallel group phase I/II marker lesion study to assess the safety, tolerability and efficacy of intravenous or intravesical pembrolizumab in intermediate risk recurrent non-muscle invasive bladder cancer
- ART: Anal squamous cell carcinoma: Investigation of functional imaging during chemoRadioTherapy
- RHYTHM-1: Modulation of Radiotherapy according to HYpoxia: exploiting changes in the Tumour Microenvironment to improve outcome in rectal cancer
- RADVAN: A randomised double blind phase 2 trial of whole brain radiotherapy with or without vandetanib in metastatic melanoma with brain metastases.
- SPARC: SBRT pre-operatively for pancreatic cancer
- VICTOR: Post-treatment stage of a Phase III, randomised, double blind, placebo-controlled study of rofecoxib (VIOXX®) in colorectal cancer patients following potentially curative therapy.
- WBRT: Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma – A randomised Phase III trial.
- QUASAR2: Multicentre international study of capecitabine ± bevacizumab as adjuvant treatment of colorectal cancer
- SONATINA: A Phase II Multi-Centre Randomised Controlled Study Of Nelfinavir Addition to Radiotherapy Treatment In Neo-Adjuvant Therapy for Rectal Cancer.
- SCOT: Short Course Oncology Treatment - A study of adjuvant chemotherapy in colorectal cancer by the CACTUS and OCTO groups.
- PanDox : Feasibility of Enhanced Chemotherapy Delivery to non-resectable Primary Pancreatic Tumours Using Thermosensitive Liposomal Doxorubicin (ThermoDox®) and Focused Ultrasound