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RESEARCH PROGRAMMES

The Effect of Oxygen Levels on the Biological Response of DNA Damage Inhibitors

Overcoming the Hypoxic Barrier to Enhance DNA Damage

Chromosome Breaks and Genome Stability

The aim of the Chromosome Integrity Group is to understand how genome stability is maintained in response to chromosomal breaks.

Protein Degradation In Cellular Response to Ionising Radiation

Investigating the importance of protein turnover in the DNA Damage Response.

The role E3 ubiquitin ligases in cancer pathogenesis and treatment with Ionising Radiation (IR)

Deciphering the role of E3 ubiquitin ligases in the pathogenesis and radiotherapy response of cancers.

Mechanistic Insights for FLASH radiation for clinical use

What is the 'FLASH effect' and how can we use it to cure cancer?

Targeting the innate immune stress response to enhance the therapeutic index of radiotherapy

Understanding how tumours exploit innate immune pathways to their advantage, and how we can target these to improve radiotherapy.

MAFF-mediated transcription regulation of redox pathways in response to radiation treatment

Determining how microenvironments affect tumour progression and radiation responses.

Figure legend: 18F-Misonidazole PET-CT scan showing a large left upper lobe tumour with lymph node metastases. Hypoxic areas of the tumour are represented by red regions on the scan.

Affiliate programme - Development of therapeutic radiosensitising compounds

Identifying and developing clinically exploitable treatments to widen the therapeutic window of radiotherapy.

The hammond group are working at the interface of the hypoxia induced unfolded protein and DNA damage responses (UPR and DDR respectively). They have recently described the induction of the DNA/RNA helicase Senataxin by the PERK-mediated arm of the UPR in hypoxic conditions (Ramchandran, Ma et al., submitted manuscript). This image highlights that both the UPR and DDR are induced with the same oxygen-dependency in hypoxia conditions (Bolland, Ma et al., Biochem Soc Trans in press 2021)

Affiliate programme - Biological response to tumour hypoxia

Investigating the biological response to tumour hypoxia and specifically, the levels of hypoxia most associated with radiation resistance.

Cellular proteolysis by the ubiquitin proteasome system UPS. Ubiquitin (represented by small black circles) is attached to protein substrates by the E1/E2/E3 conjugating system and removed by deubiquitylating enzymes DUBs (black star / red arrow). These are critical control check points for intracellular protein degradation

Affiliate Programme - Role of ISGs in sensitizing cancer cells to ionising radiation

Applying mass spectrometry to define the molecular signatures in human disease processes and accelerating target discovery in translational research.

MRC OIRO