Overcoming the Hypoxic Barrier to Enhance DNA Damage
The aim of the Chromosome Integrity Group is to understand how genome stability is maintained in response to chromosomal breaks.
Investigating the importance of protein turnover in the DNA Damage Response.
Deciphering the role of E3 ubiquitin ligases in the pathogenesis and radiotherapy response of cancers.
What is the 'FLASH effect' and how can we use it to cure cancer?
Understanding how tumours exploit innate immune pathways to their advantage, and how we can target these to improve radiotherapy.
Determining how microenvironments affect tumour progression and radiation responses.
Identifying and developing clinically exploitable treatments to widen the therapeutic window of radiotherapy.