Title

From Genome Integrity to Genome Plasticity: the Yin-Yang of DNA Replication Control

Speaker:

Professor Zoi Lygerou, University of Patras, Greece

Date & Time:

Monday, 27 July 2015, 11:00

Location: 
Old Road Campus Research Building, 71A, B and C, Headington OX3 7DQ
Host: 
Department of Oncology

Zoi Lygerou is Professor of Biology at Patras Medical School in Greece, Director of Studies of the Interdepartmental Postgraduate Program "Life Sciences Informatics" and member of the Directing Board for Research of the University of Patras. Following a degree in Biology from the University of Athens, a PhD at the EMBL in Heidelberg, and a postdoc at the London Research Institute, Zoi returned to Greece to head a research team at the University of Patras. She studies the control mechanisms which safeguard genomic stability by ensuring once per cell cycle replication in eukaryotic cells and how defects in this control may lead to tumorigenesis. Her team combines molecular-cell biology studies in human cells, genetic studies in fission yeast, analyses of tumor specimens, advanced live cell imaging and modelling of biological networks. She is the recipient of an ERC Consolidator Grant, became an EMBO Young Investigator in 2000 and an EMBO member in 2014.

PUBLICATIONS:

Rapsomaniki, M. A., Cinquemani, E., Giakoumakis, N. N., Kotsantis, P., Lygeros, J., & Lygerou, Z. (2015). Inference of protein kinetics by stochastic modeling and simulation of fluorescence recovery after photobleaching experiments. Bioinformatics, 2015 Feb 1;31(3):355-62.

Symeonidou IE, Kotsantis P, Roukos V, Rapsomaniki MA, Grecco HE, Bastiaens P, Taraviras S, Lygerou Z. (2013) Multi-step loading of human Mini-Chromosome Maintenance Proteins in live human cells. J Biol. Chem. 288(50): 35852-67

Pefani DE, Dimaki M, Spella M, Karantzelis N, Mitsiki E, Kyrousi C, Symeonidou IE, Perrakis A, Taraviras S, Lygerou Z. (2011) Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. J. Biol. Chem. 286:23234-46

Roukos V, Kinkhabwala A, Colombelli J, Kotsantis P, Taraviras S, Nishitani H, Stelzer E, Bastiaens P, and Lygerou Z (2011) Dynamic Recruitment of the Licensing Factor Cdt1 to Sites of DNA Damage J. Cell Science. 124:422-432

J. Lygeros, K. Koutroumpas, S. Dimopoulos, I. Legouras, P. Kouretas, C. Heichinger, P. Nurse, Z. Lygerou (2008) Stochastic hybrid modelling of DNA replication across a complete genome. Proc Natl Acad Sci USA. 105:12295-12300.

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