Title

The Hyperpolarized Xenon-129 (HPX) MRI: the development and optimization of novel imaging sequences, and their clinical applications

Project Code: 
ONC18FG1
Supervisor(s): 

The Hyperpolarized Xenon-129 (HPX) MRI research program focuses on the development and optimization of novel imaging sequences, and their clinical applications. The ongoing projects include development of techniques based on: 

(i) Rapid non-Cartesian k-space sampling approaches for imaging of HP 129Xe gas ventilation within the lung airways during a breath-hold interval (i.e. static imaging) and/or dynamic imaging during the entire berating cycle 
(ii) IDEAL (Iterative Decomposition of water and fat with Echo Asymmetry and Least-square estimation) approaches for imaging of HP 129Xe gas, pulmonary tissue-plasma, and perfusion compartments of lung. 
(ii) Apparent Diffusion Coefficient (ADC) imaging of gas ventilation and ADC maps 

The HPX imaging group includes an MHRA licensed polariser, with manufacturing and QP staffing, with dedicated access to MRI. Professor F Gleeson heads the imaging group with Dr T Matin, as the Academic Clinical lecturer, and Dr O Doganay as the Post Doc in HPX imaging. The group have been investigating the use of HPX in normals, patients with COPD and radiotherapy effects in lung cancer, and are now working with the academic chest unit investigating interstitial lung disease. Secondary supervision will be provided by Ozcan Doganay.

Publications include:

  1. Matin TN, Rahman N, Nickol AH, et al. Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized 129Xe MR Imaging. Radiology. 2017;282:857-68. 
  2. Doganay O, Stirrat E, McKenzie C, et al. Quantification of regional early stage gas exchange changes using hyperpolarized 129Xe MRI in a rat model of radiation-induced lung injury. Med Phys. 2016;43:2410. 
  3. Doganay O, Wade T, Hegarty E, et al. Hyperpolarized 129Xe imaging of the rat lung using spiral IDEAL. Magnetic resonance in medicine. 2016;76:566-76. 
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