The Bioanalysis Core provides support in flow cytometry and in measuring concentrations of small molecules using high performance liquid chromatography-mass spectrometry (HPLC-MS).
The Bioanalysis Core works with research groups across the Department and also supports a number of clinical studies.
Flow cytometry can determine how actively the cell is growing, how intimate processes are proceeding, whether any abnormalities are occurring, and if necessary isolate a population of interest for further study. The flow cytometry laboratory consists of three flow cytometers and a cell sorter.
The HPLC laboratory operates as a controlled access facility in order to allow the maintenance of GCP standards required for clinical studies. It is used for determination of cellular metabolites, and to measure the distribution of drugs in blood and tissues (pharmacokinetics) in clinical trials. New analytical methods are developed as required, and we also offer expertise in drug formulation and stability studies, and to confirm compound identity. There are three HPLC systems with coupled mass spectrometry, and a fourth HPLC offers alternative detection techniques.
Graham Brown studied at Cardiff University and the University Hospital of Wales and joined the Department of Oncology in 2014, taking over management of the Bioanalysis Core in September 2015.