Peter McHugh

We aim to understand how repair of damaged DNA is controlled during chromosome duplication, and why potentially dangerous changes in the behaviour of cells can occur when this process goes wrong.

Madalena Tarsounas

Our research is focused on gaining a greater understanding of how homologous recombination (HR), the major DNA repair pathway in mammalian cells, helps to prevent genomic instability, the underlying mechanism of many cancers. In particular, we study how tumor cells lacking BRCA1 or BRCA2 gene function differ from normal cells in their responses to exogenous damage induced by ionizing radiation, as well as to cell-intrinsic challenges that arise during DNA replication.

Anne Kiltie

We are investigating DNA damage signalling and repair factors in bladder cancer to develop new radiotherapy-based treatments and to identify markers to select the most suitable treatments for individual patients.

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We aim to enhance clinical and basic cancer research in Oxford with the ultimate goal of increasing cancer cure rates.
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