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The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.

Type

Journal article

Journal

Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity

Publication Date

01/01/1996

Volume

2

Pages

23 - 25