The stability and conformation of duplex DNA containing the novel anti-HIV drug ADRT.
Gibson NJ., McKellar CM., Brown T.
The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.