The protease SPRTN emerged as the essential enzyme for DNA-protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA-protein crosslinks.
Journal article
Trends Biochem Sci
01/2021
46
2 - 4
DNA–protein crosslinks, SPRTN protease, cancer, genomic instability, DNA-Binding Proteins, Humans