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The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).

Original publication

DOI

10.1016/j.apradiso.2008.06.015

Type

Journal article

Journal

Appl Radiat Isot

Publication Date

03/2009

Volume

67

Pages

436 - 439

Keywords

Animals, Bystander Effect, Cells, Cytoplasm, DNA, Genome, Humans