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Oligonucleotides hold great promise as therapeutic agents but poor bioavailability limits their utility. Hence, new analogues with improved cell uptake are urgently needed. Here, we report the synthesis and physical study of reduced-charge oligonucleotides containing artificial LNA-sulfamate and sulfamide linkages combined with 2'-O-methyl sugars and phosphorothioate backbones. These oligonucleotides have high affinity for RNA and excellent nuclease resistance.

Original publication

DOI

10.1021/acs.orglett.4c01232

Type

Journal article

Journal

Org Lett

Publication Date

17/05/2024

Volume

26

Pages

4137 - 4141

Keywords

Oligonucleotides, Molecular Structure, Sulfonic Acids, Sulfonamides, RNA