In a recent paper in Nature, Petropoulos et al.1 report that PARP1 acts together with the replisome components TIMELESS and TIPIN to protect the genome from transcription-replication conflicts, which has important implications for the clinical use of PARP inhibitors.
Journal article
Mol Cell
16/05/2024
84
1824 - 1825
Humans, Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, Poly (ADP-Ribose) Polymerase-1, DNA Replication, DNA Repair, Transcription, Genetic