Synthesis of anthraquinone oligonucleotides for triplex stabilization.
Zhao Z., Peng G., Michels J., Fox KR., Brown T.
The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.