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Stable triplexes have been generated under near-physiological conditions by the introduction of the C and T base analogues 3-methyl-2-aminopyridine-2'-deoxyriboside and 5-(3-aminoprop-2-ynyl)-'-deoxyuridine into psoralen-conjugated triplex-forming oligonucleotides. After irradiation with UV light at 365 nm, photo-induced cross-linking of the TFO to double-helical DNA was observed by UV-melting analysis and fluorescence measurements.

Original publication

DOI

10.1080/15257770701508554

Type

Journal article

Journal

Nucleosides Nucleotides Nucleic Acids

Publication Date

2007

Volume

26

Pages

1005 - 1009

Keywords

Base Sequence, Cross-Linking Reagents, DNA, Drug Design, Furocoumarins, Nucleic Acid Conformation, Nucleic Acid Denaturation, Oligonucleotides, Photochemistry, Photosensitizing Agents, Spectrometry, Fluorescence, Ultraviolet Rays