Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Tumour oxygenation is important in clinical radiotherapy because hypoxic cells are radioresistant. Knowledge of the state of tumour oxygenation would be advantageous for maximising effectiveness of treatment. A prototype fibre optic fluorosensor for measuring low (radiobiologically relevant) levels of oxygen is described. Based on oxygen quenching of the fluorescence of an excited fluorophor immobilised in a polymer at the end of an optical fibre, the sensor shows promise in overcoming some of the limitations of existing oxygen sensor systems. The prototype fibre optic sensor operates most effectively in the 0-2% oxygen range with fast response and settling times. Preliminary results from measurements in tumours are presented.


Journal article


Br J Cancer Suppl

Publication Date





S256 - S259


Animals, Fluorescence, Humans, Mice, Neoplasms, Experimental, Oxygen