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A cellular imaging system, optimized for unstained cells seeded onto a thin substrate, is under development. This system will be a component of the endstation for the microbeam cell-irradiation facility at the University of Surrey. Previous irradiation experiments at the Gray Cancer Institute (GCI) have used Mylar film to support the cells [Folkard, M., Prise, K., Schettino, G., Shao, C., Gilchrist, S., Vojnovic, B., 2005. New insights into the cellular response to radiation using microbeams. Nucl. Instrum. Methods B 231, 189-194]. Although suitable for fluorescence microscopy, the Mylar often creates excessive optical noise when used with non-fluorescent microscopy. A variety of substrates are being investigated to provide appropriate optical clarity, cell adhesion, and radiation attenuation. This paper reports on our investigations to date.

Original publication

DOI

10.1016/j.apradiso.2008.06.017

Type

Journal article

Journal

Appl Radiat Isot

Publication Date

03/2009

Volume

67

Pages

460 - 463

Keywords

Cell Adhesion, Cells, Cytological Techniques, Diagnostic Imaging, HeLa Cells, Humans, Microscopy