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The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.

Original publication

DOI

10.1016/j.clon.2018.02.031

Type

Journal article

Journal

Clin Oncol (R Coll Radiol)

Publication Date

05/2018

Volume

30

Pages

280 - 284

Keywords

Proton beam therapy, clinical trials, external beam radiotherapy