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The human epithelial antigen recognized monoclonal antibody (MAb) AUA1 has been characterized as a cell-surface glycoprotein. It has been isolated from human colonic mucosa by AUA1 affinity separation. N-terminal peptide sequence of this purified material has revealed a 17 amino acid sequence which identifies it with one of a group of similar epithelial/tumor-associated glycoproteins defined by a variety of MAbs. Using the polymerase chain reaction to map the gene encoding this antigen, our previous AUA1 antigen assignment to chromosome 2 has been confirmed.

Type

Journal article

Journal

Int J Cancer

Publication Date

15/03/1990

Volume

45

Pages

562 - 565

Keywords

Antibodies, Monoclonal, Antigens, Surface, Base Sequence, Colon, Humans, Membrane Glycoproteins, Molecular Sequence Data, Molecular Weight, Mucin-1