Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

© 2017 Elsevier Inc. All rights reserved. The Hippo tumor suppressor pathway is a developmentally conserved signal cascade that regulates tissue growth and organ size. In line with the role in suppressing growth, the pathway is being increasingly described to suppress proliferation of cancer cells. Exactly how the Hippo tumor suppressor pathway is inactivated in cancers is not fully understood, but existing evidence supports the idea that growth promoting pathways may also serve to repress pathway activity. Interestingly, Ras signaling has become an appealing candidate for Hippo inactivation as increasing reports outline how EGFR-RAS-RAF-MEK-ERK-mediated cross talk controls Hippo signaling. Here we aim to discuss the pathway cross talk in detail, outlining the existing evidence and presenting an overview of current knowledge of the interplay between RAS and Hippo pathways.

Original publication

DOI

10.1016/B978-0-12-803505-4.00002-3

Type

Chapter

Book title

Conquering RAS: From Biology to Cancer Therapy

Publication Date

30/08/2016

Pages

25 - 39