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Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.

Original publication

DOI

10.1007/s10555-007-9063-1

Type

Journal article

Journal

Cancer Metastasis Rev

Publication Date

06/2007

Volume

26

Pages

333 - 339

Keywords

Cell Division, Cell Hypoxia, Cell Movement, Cell Survival, Connective Tissue Growth Factor, Gene Expression Regulation, Neoplastic, Humans, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic