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The expression of amphiregulin (AR), heregulin (HRG), and cripto-1 (CR-1) mRNA transcripts was assessed in 60 human primary breast carcinoma. AR and HRG transcripts were expressed respectively in 58% and 25% of the carcinomas as measured by Northern blot analysis. CR-1 mRNA was found in 77% of the carcinomas using Reverse Transcriptase-PCR analysis. Coexpression of two or three of these peptides was observed in several specimens. There was no significant association between AR, HRG, and CR-1 expression and nodal status, EGF receptor, or c-erbB-2 protooncogene expression in these tumors. However, a significant association between AR expression and estrogen receptor positivity was observed.


Journal article


Breast Cancer Res Treat

Publication Date





293 - 297


Amphiregulin, Biomarkers, Tumor, Blotting, Northern, Breast Neoplasms, EGF Family of Proteins, Epidermal Growth Factor, ErbB Receptors, Female, GPI-Linked Proteins, Gene Expression, Glycoproteins, Growth Substances, Humans, Intercellular Signaling Peptides and Proteins, Membrane Glycoproteins, Neoplasm Proteins, Neuregulins, Polymerase Chain Reaction, RNA, Messenger, Receptor, ErbB-2, Receptors, Estrogen