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Genome Integrity & Epigenetics

Our basic research into genome stability explores how cells repair damaged DNA to prevent cancer. We are also interested in what happens once cancer develops, as it is becoming clear that many tumours are defective in repairing damaged DNA. Our work aims to exploit these repair defects to design novel therapies.

Our basic research into genome stability explores how cells repair damaged DNA to prevent cancer. We are also interested in what happens once cancer develops, as it is becoming clear that many tumours are defective in repairing damaged DNA. Our work aims to exploit these repair defects to design novel therapies. As a complement to this, we are using epigenetic approaches, which concern chemical changes in chromosome composition and gene expression, to understand mechanisms of inflammation and how tumours interact with the immune system. Both of these avenues of research will help us improve the clinical application of several emerging therapeutic strategies, including those that target the immune system.



Groups within this theme

Nick La Thangue
Cancer Cell Cycle

Nick La Thangue

Sarah Blagden
Cancer Therapeutics and mRNA Dysregulation

Sarah Blagden

Eric O'Neill
Cell Signalling

Eric O'Neill

Andrew Blackford
DNA Damage & Disease

Andrew Blackford

DNA Damage and Repair

Peter McHugh

Mark Middleton
Early Phase Clinical Trials & Melanoma Therapy

Mark Middleton

Madalena Tarsounas
Genome Stability and Tumourigenesis

Madalena Tarsounas

Anna Schuh
Oxford Molecular Diagnostics

Anna Schuh

Research Theme Lead Investigators