Genome Integrity & Epigenetics
Our basic research into genome stability explores how cells repair damaged DNA to prevent cancer. We are also interested in what happens once cancer develops, as it is becoming clear that many tumours are defective in repairing damaged DNA. Our work aims to exploit these repair defects to design novel therapies. As a complement to this, we are using epigenetic approaches, which concern chemical changes in chromosome composition and gene expression, to understand mechanisms of inflammation and how tumours interact with the immune system. Both of these avenues of research will help us improve the clinical application of several emerging therapeutic strategies, including those that target the immune system.