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Supporting academic research within and outside of the university, we provide specialist analytical chemistry support in the majority through HPLC-MS or HPLC-MS-MS techniques with additional UV-visible absorbance and fluorescence detection abilities.

Hplc

By providing new analytical methods as required, we support many aspects of drug development at the exploratory, preclinical and clinical study levels confirming compound identity, stability, solubility and protein binding efficiency as well as determination of cellular metabolites. We can provide expertise in the measurement of the distribution of drugs in blood, urine and tissues (pharmacokinetics) and biomarkers by ELISA (pharmacodynamics) for small phase 1/2 clinical trials under the guidance of GCP in our controlled-access laboratory. Advice on the analysis of biological samples in a laboratory under GCP guidelines can also be sought.

 

If you would like to know more about our services, and how we can help you, please contact: Lisa Folkes or Alix Hampson

 

SELECTED PUBLICATIONS

C-C. Pai, K-F. Hsu, S.C. Durley, A. Keszthelyi, S.E. Kearsey, C. Rallis, L. K. Folkes, R. Deegan, S.E. Wilkins, S. Pfister, N. De Leon, C.J. Schofield, J. Bahler, A.M. Carr, and T.C. Humphrey. An essential role for dNTP homeostasis following CDK-induced replication stress, Journal of Cell Science, 132, (2019) [PMID: 30674555]

M.D. Gray, P.C. Lyon, C. Mannaris, L.K. Folkes, M. Stratford, L. Campo, D.Y.F. Chung, S. Scott, M. Anderson, R. Goldin, R. Carlisle, F. Wu, M.R. Middleton, F.V. Gleeson and C.C. Coussios. Focused ultrasound hyperthermia for targeted drug release from thermosensitive liposomes: results from a phase I trial, Radiology, 291, 232-238 (2019) [PMID: 30644817]

T. A. Eyre, G.P. Collins, A. Gupta, N. Coupe, S. Sheikh, J. Whittaker, L.M. Wang, L. Campo, E. Soilleux, F. Tysoe, R. Cousins, N. La Thangue, L.K. Folkes, M.R.L Stratford, D. Kerr & M. Middleton. A phase I study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer, Cancer, 125, 99-108 (2019) [PMID: 30332497]

P.C. Lyon, M.D. Gray, C. Mannaris, L. Folkes, L. Campo, D.Y.F. Chung, S. Scott, M. Anderson, R. Goldin, R. Carlisle, F. Wu, F.V. Gleeson and C.C. Coussios. TARDOX: A Phase I trial investigating the safety and feasibility of ultrasound-triggered targeted drug delivery in liver tumours, The Lancet Oncology, 19, 1027-1039 (2018) [PMID: 30001990]

V.K. Woodcock, S. Clive, R.H. Wilson, V.M. Coyle, M.R.L. Stratford, L.K. Folkes, R. Eastell, C. Barton, P. Jones, H. Kazmi-Stokes, H. Turner, S. Halford, A.L. Harris and M.R. Middleton. A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424, British Journal of Cancer 118, 770-774 (2018) [PMID: 29438361]

C-C. Pai, A. Kishkevich, R. S. Deegan, A. Kaszthelyi, L. Folkes, S. E. Kearsey, N De Leon, I Soriano, R. A. Maria de Bruin, A. M. Carr and T. C. Humphrey. Set2 methyltransferase facilitates DNA replication and promotes genotoxic stress responses through MBF-dependent transcription, Cell Reports, 20, 2693-2705 (2017) [PMID: 28903048]

L.J. O'Connor, I.N. Mistry, S.L. Collins, L.K. Folkes, G. Brown, S.J. Conway and E. Hammond. CYP450 enzymes effect oxygen-dependent reduction of azide-based fluorogenic dyes, ACS Central Science, 3, 20-30 (2017) [PMID: 28149949]

A. Kotsantis, L. Marques Silva, S. Irmscher, R.M. Jones, L. Folkes, N. Gromak and E. Petermann. Increased global transcription activity as a mechanism of replication stress in cancer, Nature Communications, 7:13087 (2016) [PMID: 27725641]

T. Ashton, E. Fokas, L.K. Schughart, L. Folkes, S. Anbalagan, M. Huether, C. Kelly, G. Pirovano, F. Buffa, E. Hammond, M. Stratford, R. Muschel, G. Higgins, and W. McKenna. Increasing radiosensitivity by alleviating tumour hypoxia: a drug screen reveals atovaquone as a clinical candidate, Nature Communications, 7:12308 (2016) [PMID: 27453292]

G. Bonifert, L. Folkes, C. Gmeiner, G. Dachs and O. Spadiut. Recombinant horseradish peroxidase variants for targeted cancer treatment, Cancer Medicine, 5, 1194-1203 (2016) [PMID: 26990592]