Autoimmunity against TNF and its role in inflammatory diseases
Nominating Supervisor: Shisong Jiang
Second Supervisor: Nicola Burgess brown
Tumour Necrosis Factor (TNF) is a pro-inflammatory cytokine. It regulates a complex signalling network able to trigger cell survival, as well as cell death via apoptosis or necrosis/necroptosis. Dysregulation of these processes is a hallmark of a myriad of disorders, including most prominently inflammatory diseases and tumour.
In a previous study, we found that autoimmunity against TNF converts TNF-related apoptosis on target cells into necrosis, turning a minimum inflammatory cell death event (apoptosis) into a strong inflammatory pathogenesis (necrosis). This might have significance in inflammatory diseases such as sepsis.
A DPhil student is required to carry out the project to explore the mechanism of TNF autoimmunity related inflammation and its clinical applications.
The DPhil student will look into the mechanism of inflammation from two angles: 1) TNF related cell signalling and 2) the immune responses to TNF. Therefore, he/she will be trained to utilize cell biological methods (Confocal, flowcytometry) as well as immunological methods (antibody and T cell assays) throughout the project
Lu, W., Wang, Y., Zhang, Q., Owen, S., Green, M., Ni, T., . . . Jiang, S. (2019). TNF-derived peptides inhibit tumour growth and metastasis through cytolytic effects on tumour lymphatics.. Clinical and experimental immunology. doi:10.1111/cei.13340
Lu, W., Chen, Q., Ying, S., Xia, X., Yu, Z., Lui, Y., . . . Jiang, S. (2016). Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction. Journal of Cell Science, 129(1), 108-120. doi:10.1242/jcs.175463