Enhancing Radiotherapy Outcomes for Oesophageal Cancer
Supervisors:
Project Details:
Inhibition of ATR (a DNA damage checkpoint kinase) is currently being evaluated with radiotherapy and chemoradiation in patients with oesophageal cancer in the Cancer Research UK/MRC funded CHARIOT clinical study, whilst dose escalation is being evaluated in the SCOPE 2 clinical study. We have done initial in silico planning to show that protons significantly reduce the dose received by heart and lung and dose modelling to predict toxicity of dose escalation. Furthermore we have shown that heart substructures have a critical role in non-cancer related mortality. The aims of this project are:
- to evaluate acute and late lung and cardiac toxicity based on the radiobiological dose modelling.
- to optimise the radiotherapy delivery strategy in the pre-operative and definitive settings for oesophageal malignancies when MRI Linac or protons are used, particularly when novel radiation sensitisers or immune modulators are incorporated into the treatment paradigm.
The ideal applicant will have a background in radiation oncology, understanding of imaging in radiation oncology and radiotherapy planning.
Key Dates for October 2021 Entry
We remain open to applications for October 21 entry and welcome late applications from candidates. Please review the remaining project list or contact the Graduate Studies Office if alternative supervision by an oncology PI is being proposed.
Please note that any applications received after 9th January are not eligible for University scholarships.
Please refer to our individual course pages to check the admissions status of each course.
Contact Us
Tel: +44 (0)1865 617410
Email: graduate.studies@oncology.ox.ac.uk
Due to Covid-19, please use primarily email as staff may not have access to telephones.
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