Module 8 - Onco-Immunology and Genomics
Kerry Fisher | Mariolina Salio |
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Learning Outcomes
By the end of this module the student will be able to describe:
- The evidence base for the immune system being important in anti-tumour immunity
- What makes a good tumour antigen
- Pros and cons of adoptive T cell therapy, DC vaccination, tumour antigen vaccination
- The advantage of using bacteria or viruses to induce anti-tumour immunity
- Why checkpoint inhibitors work in only a fraction of patients
- How to study the immune response in cancer patients
- How to design a cancer vaccine
Indicative Content
This module will give insights into immuno-oncology and cover the molecular basis of tumour immunology as well as emerging and established therapies (checkpoint inhibitors, CAR T cells and adoptive T cell therapy) and how novel biomarkers in this area can be used in stratified health care; the role of microbiota; the complexity of the tumour microenvironment.