Module 8 - Onco-Immunology and Genomics

Kerry Fisher	Mariolina Salio

Learning Outcomes

By the end of this module the student will be able to describe:

1. The evidence base for the immune system being important in anti-tumour immunity
2. What makes a good tumour antigen
3. Pros and cons of adoptive T cell therapy, DC vaccination, tumour antigen vaccination
4. The advantage of using bacteria or viruses to induce anti-tumour immunity
5. Why checkpoint inhibitors work in only a fraction of patients
6. How to study the immune response in cancer patients
7. How to design a cancer vaccine

Indicative Content

This module will give insights into immuno-oncology and cover the molecular basis of tumour immunology as well as emerging and established therapies (checkpoint inhibitors, CAR T cells and adoptive T cell therapy) and how novel biomarkers in this area can be used in stratified health care; the role of microbiota; the complexity of the tumour microenvironment.