Elliot Abbott

PhD Researcher

Personalised radionuclide therapy of liver tumours

Injecting ⁹⁰Y-loaded microspheres into liver tumours by their blood supply is called selective internal radiotherapy (SIRT). SIRT benefits patients because the absorbed radiation dose is better tolerated in the liver than from conventional external beam radiotherapy (EBRT). However, while EBRT dose is prescribed in advance, SIRT dose can only be measured after it has been delivered. To address this limitation, a personalised approach is needed.

Elliot's work aims to personalise SIRT by investigating:

clinical outcomes based on absorbed dose from SIRT
the radiobiology of SIRT compared to EBRT
topping-off undertreated areas from SIRT with EBRT
emerging noninvasive imaging techniques of blood perfusion to predict SIRT dose

Recent publications

Radiosensitivity of colorectal cancer to 90Y and the radiobiological implications for radioembolisation therapy.
Journal article

Lee BQ. et al, (2019), Phys Med Biol, 64
Dosimetric Analysis of Individual Liver Metastases from Colorectal Cancer Following 90 y Microsphere Selective Internal Radiation Therapy
Conference paper

Abbott EM. et al, (2017), INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99, E132 - E132
NTCP calculations for Selective Internal RadioTherapy (SIRT) - demonstration of the methodology
Conference paper

Abbott EM. et al, (2015), EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42, S330 - S330
Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux.
Journal article

Buschmann MM. et al, (2013), Mol Biol Cell, 24, 3056 - 3068

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