c-MET is upregulated in Barrett’s esophagus and esophageal adenocarcinoma compared with normal epithelium: A and B, Upregulation of MET mRNA in Barrett’s esophagus and esophageal adenocarcinoma in two GEO databases in comparison with NSE. C, Representative immunostaining of normal epithelium, inflammation, hyperplasia, and esophageal adenocarcinoma. D, Analysis of human TMAs confirmed upregulation of c-MET protein in esophageal adenocarcinoma compared with NSE, inflammation, and hyperplasia (all P < 0.0001). E and F, Immunostaining of endoscopic human biopsy samples of NSE (n = 6) and Barrett’s esophagus (n = 5) showed an approximately 2-fold greater average H-score and percentage of c-MET positivity in Barrett’s esophagus compared with NSE. **, P < 0.01; ****, P < 0.0001.