Recurrent ERBB2 alterations are associated with esophageal adenocarcinoma brain metastases.

Lawson NM., Ye L., Cho CY., Zhao B., Mitchell T., Martín-Barrio I., Beernaert B., Gupta A., Banu M., Lissanu Y., Shaffer S., Tawbi H., Li J., Gule-Monroe MK., Alvarez-Breckenridge CA., Huse JT., Murphy MB., Yin F., Lang FF., Parkes EE., Weinberg JS., Akdemir KC.

DOI

10.1101/2025.02.19.25322558

Type

Preprint

Publication Date

2025-02-26T00:00:00+00:00

Keywords

ADC therapies, ERBB2, Esophageal adenocarcinoma, JAK2, T cell infiltration, brain metastasis, ecDNA, immunotherapy, micronuclei, tumor microenvironment

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