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Research groups

Gulsah Albayrak

BSc, MSc, PhD, DPhil, FHEA

Postdoctoral Researcher

  • Lecturer of MSc in Applied Cancer Science

RESEARCH SUMMARY

My research focuses on advancing our understanding of T-cell biology and its applications in cancer immunotherapy with a particular emphasis on solid tumours; those main areas:

  • T-cell Exhaustion: Investigating the cellular and molecular mechanisms underlying T-cell exhaustion, a state of dysfunction that impairs anti-tumour immune responses. The goal is developing strategies to prevent/reinvigorate exhausted T-cells.
  • Optimizing T-cell Engagers: Improving bispecific antibodies that redirect T-cells to tumour cells, exploring their mechanisms of action and refining their design for improved therapeutic outcomes. 

By integrating these two research focuses, our aim is to translate findings into novel and more effective cancer treatments, ultimately improving patient outcomes in solid tumour malignancies.

BIOGRAPHY

Gulsah completed her DPhil in Oncology at the Department of Oncology, University of Oxford, focusing on PRMT5's role in cancer. Gulsah is now a Post-Doctoral Scientist in the Department of Oncology at Oxford, specializing in T-cell exhaustion and cancer biology. An experienced mentor and lecturer, Gulsah has been awarded Fellowship of the Higher Education Academy (FHEA). She also co-leads MSc Applied Cancer Science module.