In a recent paper in Nature, Petropoulos et al.1 report that PARP1 acts together with the replisome components TIMELESS and TIPIN to protect the genome from transcription-replication conflicts, which has important implications for the clinical use of PARP inhibitors.
Journal article
2024-05-16T00:00:00+00:00
84
1824 - 1825
1
Humans, DNA Repair, DNA Replication, Neoplasms, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, Transcription, Genetic, Cell Cycle Proteins, Intracellular Signaling Peptides and Proteins