Matthew Jackson

My current research centres around  fundamental mechanisms governing immune cell function and anti-tumour immunity, with a particular focus on biology pertaining to the endoplasmic reticulum (ER) in CD8+ T cells. The ER is a dynamic immunoregulatory hub within the cell, home to a multitude of functional membrane proteins and their cofactors which collectively fine-tune processes involved in anti-tumour immunity, including antigen presentation, innate immune signalling and calcium homeostasis. Understanding how these processes occur in the context of tumour challenge holds promise in unveiling new avenues for cancer immunotherapy. 

Matt recently completed his DPhil in Prof. Eileen Parkes' lab ( Department of Oncology),  co-supervised by Prof. John Christianson (Botnar Research Centre) where he investigated novel regulatory mechanisms governing the STING (STimulator of INterferon Genes) pathway and anti-tumour immunity. Prior to this, Matt acquired a BSc in Biological Sciences from Durham University, during which time he undertook an industrial research placement in the Discovery Sciences unit at AstraZeneca (Gothenburg, Sweden), as well as summer studentships in Prof Sarah Blagden's lab (Department of  Oncology, University of Oxford). 

In his free time, Matt enjoys rowing, singing and running.