Tiffany S. Ma
Tumour hypoxia and oxidative stress
My research investigates the role of oxidative stress and structures called R-loops in hypoxia, with a focus on transcription. Hypoxic tumours are known to be radio- and chemotherapy resistant and are associated with metastasis and poor patient prognosis. Therefore, deepening our understanding of the defence mechanisms of hypoxic tumours can help us create targeted therapies.
I graduated from University of California, Berkeley with a B.A. in Molecular Cell Biology (2017) and minors in Bioengineering and Gender & Women's Studies. I then completed my Masters in Translational Medicine (2018), a joint degree between UC Berkeley and UC San Francisco, during which I worked for an early stage medical device start-up. I completed my DPhil in Oncology at the University of Oxford with Professor Ester Hammond studying links between the DNA damage response and the unfolded protein response.
I am now a postdoctoral researcher in the Department of Oncology.
Ramachandran, S.*; Ma, T. S.*; Griffin, J.; Ng, N.; Foskolou, I. P.; Hwang, M. S.; Victoria, P.; Cheng W.C.; Buffa, F. M.; Leszczynska, K. B.; El-Khamisy, S. F.; Gromak, N.; Hammond, E. M. Hypoxia-induced SETX links replication stress with the unfolded protein response. Nat. Commun. 17 June 2021.
Bolland, H.*; Ma, T. S.*; Ramlee, S.; Ramadan, K.; Hammond, E. M.; Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review. Biochem. Soc. Trans. 18 May 2021.
Bader, S., Ma, T. S.; Simpson, C. J.; Liang, J.; Maezono, S. E. B.; Olcina, M. M.; Buffa, F. M.; Hammond, E. M.; Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity. Nucleic Acids Res. 21 July 2021.