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Yanti De Visser
MSc by Research
BRCA1 and BRCA2 play a key role in double-strand break repair mediated by homologous recombination. Deficiency in one of these proteins results in DNA damage accumulation with subsequent genome instability and increased risk of cancer development. Treatment of these BRCA1/2-deficient cells and tumours with G-quadruplex ligands are proven to be effective earlier in our lab, potentially by innate immune response activation. Another drug, taxol-based, already used for the treatment of various cancers in the clinic, might have a synergistic effect in a co-treatment with a G-quadruplex ligand by accelerating innate immune response activation and induced apoptosis. It is my aim to investigate this synergy and the underlying mechanism of innate immune response activation.
I obtained my BSc in Bioscience engineering at the University of Antwerp, Belgium, in 2017. I then continued my academic career with an MSc in Bioscience engineering: Cell and gene biotechnology at Ghent University, Belgium. I conducted my Master dissertation "Characterisation of less toxic variants of L-asparaginase for treatment of leukaemia" in collaboration with the University of Illinois at Chicago, USA in 2019.
Super Science Saturday
I'm proud that I could contribute to the public engagement project of the department at Super Science Saturday in The Museum of Natural History. We explained how DNA works and how a fluorescent protein from the jelly fish Aequorea Victoria can help cancer research.