Postdoctoral Researcher - Bioinformatics/Statistics

We have a new and exciting opportunity for a Postdoctoral Researcher with experience in Bioinformatics to work in the team led by Dr Benjamin Fairfax. The aim of the group is to research chronic inflammation results in an immune environment associated with the development and progression of cancers.
Comparatively little is known regarding the systemic effects of cancer on immunity and there are few studies investigating how cancer affects immune cell genomics. Our previous work has focused on exploring how environmental and cellular context interacts with genetic variants to regulate immune cell transcriptomics (see Fairfax et al Nat. Gen., 2012, Fairfax et al Sci. 2014, Naranbhai et al Nat. Comm. 2015). The management of many cancers is being transformed by the widespread adoption of checkpoint inhibitor based immunotherapy to treat multiple tumour subtypes. A comprehensive understanding of the interactions between host genotype and immunity will therefore be of high importance in deciphering the immune response to cancer and understanding the basis behind divergent treatment responses.
The postholder would be involved in the development and implementation of methods including those predictive of treatment outcome from transcriptomic data. In addition, it is expected that they would play a significant role in the supervision of statistical and bioinformatic analyses performed by DPhil and Clinical research fellows.
You will hold a PhD in statistical genetics, computer science, bioinformatics or other closely related area, with extensive experience in next-generation sequencing (ideally RNA-seq data and/or ChIP-seq). You will be have demonstrable experience in manipulating genome-scale datasets and in employing employing machine learning algorithms (ideally with experience in Bayesian methodology).
Demonstrable experience of student supervision will be advantageous.
This is a full-time post is available for 3 years in the first instance.
All applicants must complete a short application form and upload a CV and supporting statement. To apply for this role, please click on the ‘Apply Now’ button in the link below.
The closing date for applications is 12.00 noon on 8 May 2017.

Closing Date: 
Monday, May 8, 2017 - 12:00
CRUK/MRC Oxford Institute for Radiation and Oncology
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