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Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.

Gupta AK., McKenna WG., Weber CN., Feldman MD., Goldsmith JD., Mick R., Machtay M., Rosenthal DI., Bakanauskas VJ., Cerniglia GJ., Bernhard EJ., Weber RS., Muschel RJ.

PURPOSE: Locoregional recurrence is the dominant form of treatment failure in head and neck (H&N) cancer. The epidermal growth factor receptor (EGFR) is frequently amplified in this disease (

Type

Journal article

Publication Date

2002-03-01T00:00:00+00:00

Volume

8

Pages

885 - 892

Total pages

7

Keywords

Adult, Aged, Aged, 80 and over, Blotting, Western, Carcinoma, Squamous Cell, Cell Division, Chromones, Dose-Response Relationship, Radiation, Enzyme Inhibitors, ErbB Receptors, Female, Gefitinib, Humans, Immunoenzyme Techniques, Male, Middle Aged, Morpholines, Neoplasm Recurrence, Local, Neoplasm Staging, Oropharyngeal Neoplasms, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Prognosis, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Quinazolines, Radiation Tolerance, Signal Transduction, ras Proteins